Professor Chris Goodnow

Chris Goodnow

Chris Goodnow

Elected in 2002

Short citation at year of election

Professor Goodnow has pioneered the use of mouse molecular genetics for studying the mechanisms of immunological tolerance to self antigens. He devised a novel double-transgenic mouse strategy that revolutionised the field, confirmed the existence of B and T cell clonal energy, and revealed multiple processes for B cell and T cell clonal deletion in vivo. His work changed the conceptual framework of tolerance by showing that it is acquired through a series of regulatory checkpoints at many steps in lymphocyte maturation. The elucidation of these 'peripheral tolerance' checkpoints acting on mature and already-activated lymphocytes has fostered practical efforts to induce or restore tolerance in adults during transplantation and autoimmunity.

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