Professor Christina Mitchell has made fundamental discoveries in biochemistry in the field of intracellular signalling by characterising families of signal regulating enzymes, including the inositol-polyphosphate 5-phosphatases, and 4-phosphatases (INPP4A and B). Her laboratory demonstrated the regulation of phosphoinositide signalling by these enzymes, showing their intracellular location and revealing the substrate specificity of phosphoinositide phosphatases. Her group determined the 5-phosphatase catalytic domain that enabled identification of all ten 5-phosphatase family members and demonstrated their cellular roles in development, cell proliferation and cytoskeletal dynamics. Professor Mitchell has made substantive contributions to research leadership, building research excellence, and mentoring early career and women researchers.