Distinguished for his ability to relate concepts derived from physics, chemistry and mathematics to the study of fundamental responses of biological membranes during the transmission of excitation. This approach has led to better understanding of the mechanisms responsible for release from nerve-endings of transmitter substances, and their mode of action on postsynaptic membranes. Gage's work is characterised by his ability to identify fundamental processes and to find means of studying these using techniques and preparations which are simple but chosen with imagination. He has become a leader in neurophysiology in Australia, and his collaboration is much sought after by his colleagues overseas.