Professor Joseph Trapani

Professor Joseph Trapani

Joseph Trapani

Elected in 2018

Short citation at year of election

Joe Trapani is an immunologist whose research focuses on how cells of the immune system kill harmful cells - those infected with a virus or undergoing cancerous transformation. Trapani discovered several diverse toxins that mediate cell death, and determined how they function, individually and in synergy. His studies also address structure/function relationships for the pore-forming protein perforin and the signalling pathways activated by the ‘granzyme’ proteases to induce target cell apoptosis. Trapani also elucidated how defects in cell death pathways impinge on human health and disease, and how immune ‘killer cells’ can be harnessed as therapies for cancer, viral and auto-immune diseases.

© 2019 Australian Academy of Science