Medical SciencesHelicobacter PyloriMicrobiologyGastroenterology
Citation at year of election
Professor Marshall discovered that infection of the stomach with uncharacterised spiral bacteria caused gastritisdyspepsia and gastroduodenal ulceration, and predisposes to gastric cancer. This profound discovery was a remarkable fulfilment of Koch's postulates, based on astute clinical and laboratory observations combined with a dramatic self-infection experiment showing conclusively that cultured bacteria induced gastritis. Marshall characterised the ulcerogenic bacterium as a new species Helicobacter Pylori established growth dependence on urea and developed diagnostic tests for its presence and eradication. His observations are a major contribution to microbiology, have revolutionised treatment of gastroduodenal ulcers, by enabling cure with antibiotics, and will substantially reduce the prevalence of gastric cancer.